Preventive Measures and Spread of COVID-19 Infection among Dental students in Basra in the First Period of the Epidemic in Iraq: An Online Cross-Sectional Survey

This study was undertaken in the college of the Dentistry-University of Basra, Oral and maxillofacial surgery Department. This survey assessed protective measures regarding COVID-19 infection and aimed to evaluation the evidence on the affiliation between use of preventive measures and COVID-19 infection among dental students in Basra. The questionnaires were designed and assembled into two domains as follows: 1-Personal data including age, sex, and academic stage. 2-Analytical data including questions regarding infection rate among dental students and their commitment of COVID-19 preventive measures. An explanation for the aim of this study was coupled to the questionnaire, and the members were asked to sign an online informed permission. The questionnaires were directed toward 1000 dental students and only 875 were responding to the survey and included in the databank. The duration of study approximately takes 10 days, the questionnaire was conducted to students on February, 12th 2020 and the documents collecting were closed at (February, 22nd 2020). On the topic of preventive measures follow in order to avoid the dispersion of COVID-19 infection, an endemic feature of Corona virus disease has led to the deaths of thousands of individuals across several countries. For the prevention of the extent of the disease and its mortality, several preventive measures have been recommended. Conversely, the level of acquaintance and the implementation of such protective measures against COVID-19 among dental students in Basra which constitute vulnerable group are yet to be evaluated. Eight-hundred and seventy-fife questionnaires were analysed. Out of the 875 participants, (250) were males, and (675) were females. Two hundred and sixty-one (29.8%) participants had been infected with covid-19, and six hundred and fourteen (70%) were not being infected. Regarding the correlation between the infection with COVID-19 and the sex and college stage, consequently, no substantial statistical differences were detected between the males and females amongst COVID infected students. This survey demonstrated that the terms of self-protective means in addition to community disaffection will be considerably drops the statistics of dental student's COVID infections.Copyright © RJPT. All right reserved.

Application of Ultrasonic Sensor and IR Sensor in Automatic Alcohol Hand Sanitizer

Hygiene is necessary to maintain human health. Hygiene keeps the body clean and free from germs, preventing the spread of diseases, which has been especially important during the COVID-19 pandemic. For this reason, we designed automatic alcohol hand sanitizers (AAHSs): one with an IR sensor and one with an ultrasonic sensor. The sanitizers will help prevent germs from spreading via the hands of people because no part of each device need be touched during its use. The AAHS with the ultrasonic sensor has various advantages over that with the IR sensor: it is 32% cheaper to produce, easier to configure and maintain, has a higher average score for user satisfaction, is smaller and more portable, and can use rechargeable batteries. In addition, its low cost makes it more suitable for commercialization. It can also be installed both outdoors and indoors. In an outdoor test, it was demonstrated to operate flawlessly. This paper includes useful information on the components of the AAHSs with the two types of sensor and an evaluation of their performance using confusion matrices. © 2023 M Y U Scientific Publishing Division. All rights reserved.

Coronavirus Disease (COVID-19) Possible Transmission Routes and Alleviation Strategies

Coronavirus disease is a contagious respiratory ailment that has spread significantly around the world. Most cases of COVID-19 are spread from person to person by coming into contact with respiratory droplets that are released when an infected person coughs or sneezes. In this manuscript, we have highlighted the possible transmission of COVID-19 through food, water, air and paper. In the case of food, we have extensively covered the transmission of COVID-19 through meat, frozen foods, food packaging and food market along with the incidences worldwide. In the nextsection, we have highlighted the different components of air which are responsible for the transmission and also covered its relation with PM 2.5 incidence. The SARS-CoV-2 was isolated from sewage water/wastewater of various countries namely the United States, India, Australia, Netherlands and France signifying that wastewater can be a mode of virus transmission. The paper circulation by the infected COVID-19 patients can also be a virus conveyance route. It can be concluded that SARS-CoV-2 can therefore be transmitted indirectly through food via the workers involved in food packing or food marts.By following general safety precautions (wearing masks, using hand sanitisers, cleaning and disinfecting contact surfaces, and avoiding close contact), heating and using chemicals like ethanol (67-71%), sodium hypochlorite (0.1%) and hydrogen peroxide (0.5%) on environmental surfaces, along with vaccination, it is possible to reduce the spread of the SARS-CoV-2 virus.Copyright © 2023 The International Journal of Pharmaceutical Research and Allied Sciences (IJPRAS).

Knowledge and Practices of Disinfectants and Sanitizers Use during COVID-19 Pandemic in Jordan

Background: The use of antimicrobials has been expanded during the COVID-19 pandemic. This study aims to assess the knowledge and practices of disinfectants and sanitizers use among Jordanian people during the (COVID-19) pandemic. Methods: A web-based cross-sectional descriptive questionnaire was distributed across Jordan between August and September 2020. The questionnaire consisted of three sections inquiring about demographics and general characteristics of the surveyed sample, evaluating the respondents' knowledge about disinfectants, as well as respondents' practices. The questionnaire was completed by 403 literate adult respondents. Results: Our results indicate that Jordanian adults have used disinfectants increasingly during the COVID-19 outbreak. Knowledge of our study sample was considerably affected by gender (p=0.044), income (p=0.001), and profession (p<0.001). 80.8% of those participants reported skin-related side effects due to disinfectant use during the pandemic. The most used disinfectants were ethanol, followed by soap and water. Generally, study respondents showed positive practices toward the use of disinfectants during the time of the pandemic with few high-risk practices reported. Interestingly, the positive practices applied by Jordanian adults were minimally and not significantly affected by the knowledge about antimicrobials' safe and effective use. Conclusions: There is an urgent need for a structured effort to increase public awareness regarding the safe and effective use of disinfectants against SARS-CoV-2 transmission. © 2023 DSR Publishers/The University of Jordan.

The danger of the toxicity and inefficacy of alcohol-based hand rubs in Iran during COVID-19: a cross-sectional study.

BACKGROUND: The use of disinfectants and alcohol-based hand rubs (ABHR) to prevent COVID-19 transmission increased in the first wave of the infection. To meet the increased demand, the Iranian Ministry of Health issued an emergency use authorization allowing new manufacturers to enter the market, despite the limited capacity for surveillance of these products during COVID-19. Methanol poisoning outbreaks spread rapidly, and more people died from methanol poisoning than COVID-19 in some cities. The aim of this study was to analyze some ABHRs in the Iranian market to see if (a) ABHRs are standard and suitable for hand antisepsis and (b) contained potentially dangerous toxic alcohols. METHOD: Between February and March 2020, 64 brands of ABHR were conveniently collected from pharmacies, supermarkets, and shops selling hygienic products and analyzed using Gas Chromatography. World Health Organization and Food and Drug Administration guidelines were used to define minimum requirements for ABHR. For estimating the risk for acute methanol poisoning, we assumed a serum methanol concentration of 200 mg/L following ABHR ingestion was sufficient to cause intoxication. This threshold concentration would be achieved in an average 75-kg adult after consuming 8000 mg (or eight grams) methanol in 1-2 h. RESULTS: The median [IQR] (range) concentration of ethanol, isopropanol, and methanol were 59% v/v [32.2, 68] (0, 99), 0 mg/L [0, 0] (0, 197,961), and 0 mg/L [0, 0] (0, 680,100), respectively. There was a strong negative correlation between methanol and ethanol contents of hand rubbers (r= -0.617, p < 0.001). Almost 47% of ABHRs complied with minimum standards. In 12.5% of ABHRs, high concentrations of methanol were observed, which have no antiseptic properties but could cause acute methanol poisoning if ingested. CONCLUSION: COVID-19 initiated a policy for distribution and use of ABHR with little control. As ABHR and masks are still accepted preventive measures of the disease, non-standard ABHR compositions may increase the population's risk to both COVID-19 infection and methanol poisoning.

Effectiveness of hand sanitizers in the prevention of COVID-19 and related public health concerns: A review

The COVID-19 pandemic poses a severe threat to public health, resulting in high levels of mortality and morbidity. In response, there has been a significant usage of hand sanitizers in homes, public places, and healthcare systems. In the global panic, the market has a variety of products, and there are serious concerns about the safety and the potential of hand sanitization as the blue bullet for COVID-19. Therefore, this article presents a critical review of types of hand sanitizers available on the market, their active ingredients coupled with their mode of action in the wake of antiviral efficacies. In addition, the adoption of a culture of hand sanitization by society could raise the demand for hand sanitizers for an extended period. The continuous use of hand sanitizers might pose some safety concerns. Consequently, the review articulates potential dangers associated with hand sanitizer used to equip suppliers and manufacturers with knowledge on the safety of different ingredients and formulations, hence safeguarding the final users.Copyright © 2022 The Author(s). This open access article is distributed under a Creative Commons Attribution (CC-BY) 4.0 license.

Screening of Natural Antivirals Against the COVID-19 Pandemic-A Compilation of Updates

Coronavirus disease 2019 (COVID-19), named by WHO, is a real public health disaster of the third millennium. This highly contagious viral disease has infected the world population and is now a global pandemic. This acute respiratory distress syndrome (ARDS) has severe complica-tions like pneumonitis, respiratory failure, shock, multiorgan failure, and death. Well-defined FDA-approved synthetic is not yet available. Case management strategies like lockdown, use of masks and sanitizers, social distancing, and repurposing of antiviral drugs were initially undertaken to cope with this pandemic. Different broad-spectrum antiviral drugs are being repurposed as one of the treatment modalities. The global vaccination programme with the newly launched COVID-19 vac-cines, Covishield, covaxin, sputnik V, etc., is an ongoing process. Simultaneously, significant research is being carried out in search of natural antivirals and evaluating the potency of food bioac-tives to aid naturistic protection against the coronavirus. This mini-review has compiled the latest updates on the screening and evidence-based mechanistic evaluation of phytochemicals and food bioactives as non-pharmacological adjuvant aid in COVID pandemics.Copyright © 2023 Bentham Science Publishers.

Fragranced hand gels: beware the risk of contact allergy

An 11-year-old boy presented to the children's Emergency Department in Autumn 2020 with acute blistering of his palms. No other parts of the body or mucosal surfaces were involved. He was systemically well, with no significant past medical history except for eczema in early childhood. He had recently started back at school and was using hand gel regularly as part of precautions to reduce SARS-CoV-2 (COVID-19) transmission during the pandemic. There had been no other contact with chemicals, plants, crafting materials, glues, paints or homemade slime. Clinical photographs showed swelling and large bullae on the thenar eminence and lateral fingers. There was no erythema, nail involvement or significant scaling. The clinical diagnosis was acute pompholyx that was either irritant or allergic in origin. Testing to the standard series showed inconclusive results to some fragrances in the standard series. The patch testing to fragrance in the standard series was repeated and the fragrance series was added. The repeat test confirmed allergic contact dermatitis to fragrance with a positive to Myroxylon pereirae, linalool, limonene, sandalwood oil and majantol. The hand gels were found to contain linalool and limonene. To curb the spread of COVID-19, regular handwashing and the use of alcohol-based hand sanitizers/gels are part of everyday hygiene guidance for the general public. Therefore, the incidence of hand dermatitis is likely to rise. The World Health Organization and the Food and Drugs Administration advise that a minimum alcohol content of 60% is required to inactivate viral particles;however, it is also important to be aware that hand sanitizers/gels may also contain other constituents, including thickeners, humectants (e.g. propylene glycol) and fragrance. Research into the ingredients of 10 widely used hand sanitizers recently investigated by an independent watchdog for their alcohol content found that six had their ingredients listed online and five contained fragrance. The patient responded to topical treatment with a superpotent topical steroid cream (Dermovate) twice daily, white soft paraffin 50 : 50, an antiseptic emollient (Dermol 500) to wash the hands and allergen avoidance. We highlight to other dermatologists that contact allergy to fragrance or other components in hand sanitizer/gels may present acutely with pompholyx and to consider testing to the standard and fragrance series if this is suspected.

Identification of Adulteration in Hand Sanitizers of Jaipur City Using Raman Spectroscopy

Hand hygiene has been established as an important part of our lives leading to reduction of colonization and communicable diseases for all. Since the World Health Organization (WHO) declared COVID-19 a global pandemic, fake hand sanitizers have appeared on the market often, posing risk to the public due to the undeclared addition of methanol and Iso-propanol. This study examined the chemical components stated on the hand sanitizer component label and investigated how people used hand sanitizer and their level of chemical awareness. 30 distinct samples, both brand-name and locally produced, were gathered from Jaipur's local markets. In addition, the samples' iso-propanol and methanol contents were examined using Raman spectroscopy. The findings of this study demonstrate that almost 37% of the samples were adulterated which is still a minacious stats considering the consumption and effects these sanitizers are having on the consumers. The adsorption of such adulterated sanitizers through skin causes irritations on skin and hands which may lead to inflammation and can also have carcinogenic effects. So, the study concludes that the identification and quality assessment of such sanitizers should be done on a large scale to prevent the spread of toxicity.Copyright © 2022, Medico Legal Society. All rights reserved.

Automatic Hand Sanitizer and Body Temperature Measurement System with Low Liquid Hand Sanitizer Condition Notification

Coronavirus disease (Covid-19) still exists, but the implementation of health protocols, namely maintaining distance, wearing masks, and washing hands (3M) is not optimal and has received more attention lately. Previous studies applied the IoT concepts to hand sanitizer systems and automatic body temperature measurements. However, this research has not been optimal for system integration in solving problems. Existing research only focuses on temperature sensor readings which can be monitored in real-time by installing third-party applications first. Therefore, we make an automatic hand sanitizer and body temperature measurement system equipped with low liquid hand sanitizer condition notification by implementing modifications using PHP MySQL website and notification feature via Twilio bot integrated with WhatsApp. The feature is based on previous research proposals. Based on the test results, the performance of the system prototype is considered good. The system prototype can produce an average of 1.1 mL as the recommended average hand sanitizer in one use of less than 1.74 mL. Then the system prototype has a hand sanitizer fluid accuracy of 90.4% and an accuracy of MLX90614 temperature sensor of 99.9%. © 2022 IEEE.

Post Vaccination Adherence to Covid Appropriate Behavior: A Cross Sectional Study

Introduction: COVID-appropriate behavior refers to the development of those habits that may serve to limit the disease's spread and, thus, reduce the number of individuals affected. Vaccinated individuals may be less willing to comply with COVID-appropriate conduct due to their perception of a diminished health risk. Consequently, the present study was conducted to assess public's attitude regarding COVID preventive measures following vaccination.. Methodology: This cross sectional study was conducted among adults aged 18 and above. 200 individuals who had received either both doses of COVID-19 or at least one dosage of either COVID-19 participated in this survey, which was performed online and involved the distribution of a self-administered questionnaire via social media. Result(s): Covishield was the most commonly administered vaccination (70%), followed by Covaxin (23%). The majority of respondents adhered to mask use after vaccination (82,5%), but 15% of respondents adhered to mask use less after vaccination than before. 2.5% of respondents reported an increase in mask use. Physical distancing was shown to be less after vaccination among (65.5%) than before vaccination. 19% of study participants reported that their frequency of hand washing with soap and water decreased following vaccination. 31% of respondents said that their usage of hand sanitizer dropped following vaccination. Conclusion(s): It should be stressed to the public that getting vaccination does not make them invincible foe the various new strains in circulation of the virus. Strict policy making should be emphasized to make people follow COVID appropriate behavior at all times.Copyright © 2023, Institute of Medico-legal Publication. All rights reserved.

Reduced norovirus epidemic follows increased sales of hand hygiene products in Japan, 2020-2021.

During the recent emergence of COVID-19, an increased practice of hand hygiene coincided with the reduced incidence of the norovirus epidemic in Japan, which is similar to experience with the pandemic flu in 2009. We investigated the relationship between the sales of hand hygiene products, including liquid hand soap and alcohol-based hand sanitizer, and the trend of norovirus epidemic. We used national gastroenteritis surveillance data across Japan in 2020 and 2021 and compared the base statistics of incidence of these two years with the average of the previous 10 years (2010-2019). We calculated the correlations (Spearman's Rho) between monthly sales of hand hygiene products and monthly norovirus cases and fitted them to a regression model. In 2020, there was no epidemic, and the incidence peak was the lowest in recent norovirus epidemics. In 2021, the incidence peak was delayed for five weeks to the usual epidemic seasons. Correlation coefficients between monthly sales of liquid hand soap and skin antiseptics and norovirus incidence showed a significantly negative correlation (Spearman's Rho = -0.88 and p = 0.002 for liquid hand soap; Spearman's Rho = -0.81 and p = 0.007 for skin antiseptics). Exponential regression models were fitted between the sales of each hand hygiene product and norovirus cases, respectively. The results suggest hand hygiene using these products is a potentially useful prevention method against norovirus epidemics. Effective ways of hand hygiene for increasing the prevention of norovirus should therefore be studied.

Antimicrobial Efficacy Assessment and Rheological Investigation of Two Different Hand Sanitizers Compared with the Standard Reference WHO Formulation 1.

(1) Background: recently, the use of alcohol-based hand sanitizers (ABHSs) has become very frequent, and an evaluation of the stability and effectiveness of their formulations is a critical topic which should be carefully considered. (2) Methods: starting from the characterization of the hand sanitizers object of the study, our interest was focused on their rheological behavior in order to confirm their intrinsic features, but also the stability of each formulation in different conditions of shear and temperature; the second aspect concerns the antimicrobial assessment through a panel of in vitro and in vivo experimental trials. (3) Results: rheological investigation confirmed good stability for the two hand sanitizers in gel formula with respect to the reference in liquid formula; the antimicrobial activity evaluation showed good efficacy of each formulation both in vitro and in vivo. (4) Conclusions: altogether, our overview presents a valid quality control assessment to ensure the stability and efficacy of an alcohol-based hand sanitizer.

Impact on touch DNA of an alcohol-based hand sanitizer used in COVID-19 prevention.

In the last years, forensic research has been focused on touch DNA in order to improve its evidential value in criminal activity investigations as well as to understand the variables impacting touch DNA. One of the emerging variables is represented by the use of alcohol-based sanitizers, which was suggested for hand hygiene during the COVID-19 pandemic. The aims of the present study were to assess the effect of a hand sanitizer on touch DNA deposition, transfer, and recovery and also to evaluate STR typing success, quality of DNA profiles, and personal identification. Before and after the use of an alcohol-based hand sanitizer, 20 volunteers deposited on glass surfaces 120 fingerprints, containing skin-derived or salivary DNA. Samples were quantified by real-time quantitative PCR (q-PCR), and 76 samples yielding > 15 pg/µl were typed for 21 autosomal STRs by GlobalFiler® PCR Amplification Kit. DNA profiles were classified into single source, mixed, and inconclusive profiles, and a LR assessment was performed by comparison to the reference samples using LRmix Studio software. After the use of hand sanitizer, samples yielded lower quantities of recovered transferred DNA, especially considering samples containing salivary DNA (p < 0.05 by Friedman test). All the 76 amplified samples (63.3% of the total) showed at least 10 typed loci, and 83-100% of profiles were consistent with the reference ones on the basis of a LR value ≥ 106. Results showed that, although the hand sanitizer reduces the DNA recovering, touch DNA samples might still be useful for forensic personal identification even when hand sanitizers are used.

Development and validation of seven phosphatidylethanol-homologues in dried blood spots including preliminary results after excessive use of an ethanol-based hand sanitizer.

Phosphatidylethanol (PEth) has become a widespread marker offering an up to four weeks retrospective window to detect alcohol use. Due to the COVID 19 pandemic, ethanol-based hand sanitizers are frequently used. The aim of this study was to develop and validate a method for determination of up to seven different homologues of PEth from dried blood spots (DBS) after use of an ethanol-based hand sanitizer. Objectives of its preliminary application were to prove whether a threshold of 20 ng/mL for PEth 16:0/18:1 is reached and whether other homologues are formed as well as if positive findings of urinary ethyl glucuronide (UEtG) can be observed with respect to assess monitoring of abstinence control programs. Ten volunteers (8 occasional, 2 regular drinkers) were recruited to excessively use an ethanol-based hand sanitizer on 5 successive days. Dried blood spots and urine samples were collected daily. PEth and UEtG were determined by LC-MS/MS. In total, two volunteers with initial PEth 16:0/18:1-concentrations of 19.3 and 14.6 ng/mL exceeded the threshold of 20 ng/mL six times. Regular drinkers had starting PEth 16:0/18:1-concentrations of 242 and 354 ng/mL, showing a decline of PEth-concentrations in six out of the seven homologues over five days. In teetotalers, formation of PEth species could not be observed. Thus, not satisfying requirements in an alcohol monitoring program with initial PEth-negative blood cannot be explained by a frequent use of ethanol-based hand sanitizer only. In cases of regular alcohol consumption, PEth-homologues are not likely to be further influenced. However, results indicated that individuals with a PEth-concentration close to 20 ng/mL are at risk of exceeding the threshold by using ethanol-based hand sanitizer.

Hand Sanitizers' Consumer Purchase Decision-Adapted Model, Testing And Validation

The first thing the COVID-19 teaches the public is to keep your hands clean and safe. The demand for hand sanitizers has suddenly grown because using these products is one of the strategies to defend against COVID-19. Sanitizers and masks were classified "necessary goods" by the Indian government under the Essential Commodities Act. The government has set the price of a 200ml bottle of hand sanitizer at Rs.100/-. Furthermore, the Indian government set the price of sanitizers at 2ml for no more than Re.1/-.The objectives of the research study are to adapt the five-stage consumer decision making model (Kotler et al. (2009)) for the hand sanitizer product in the COVID-19 scenario and to adapt and define the scale items related to each stage of the consumer decision making process with regard to the hand sanitizer product. The findings indicate that consumers demonstrate regular purchasing behaviour when they are happy with an emergency product (hand sanitizer product in covid-19 scenario). Consumers will prefer to acquire emergency-related products solely from approved stores (like medical outlet).

Impact of COVID-19 pandemic waves on health-care worker hand hygiene activity in department of medicine and ICU as measured by an automated monitoring system.

BACKGROUND: Hand hygiene (HH) compliance among health-care workers is important for preventing transmission of infectious diseases. AIM: To describe health-care worker hand hygiene activity in ICU and non-ICU patients' rooms, using an automated monitoring system (AMS), before and after the onset of the COVID-19 pandemic. METHODS: At the Intercommunal Hospital of Créteil, near Paris, France, alcohol-based hand sanitizer (ABHS) consumption in the Department of Medicine (DM) and ICU was recorded using an AMS during four periods: before, during, and after the first wave of the COVID-19 pandemic, and during its second wave. FINDINGS: From 1st February to 30th November 2020, in the DM, the mean number of doses per patient-day for each of the four periods was, respectively, 5.7 (±0.3), 19.4 (±1.3), 17.6 (±0.7), and 7.9 (±0.2, P < 0.0001). In contrast, ICU ABHS consumption remained relatively constant. In the DM, during the pandemic waves, ABHS consumption was higher in rooms of COVID-19 patients than in other patients' rooms. Multivariate analysis showed ABHS consumption was associated with the period in the DM, and with the number of HCWs in the ICU. CONCLUSION: An AMS allows real-time collection of ABHS consumption data that can be used to adapt training and prevention measures to specific hospital departments.

Dermatological impact of hand hygiene practices during COVID-19: A cross-sectional web-based survey among doctors in a tertiary care hospital in Eastern India.

BACKGROUND: The COVID-19 pandemic continues to persist throughout the world with intermittent exacerbation. The changing trend of hand hygiene practices during this pandemic has led to new onset or aggravation of pre-existing hand eczema, especially among doctors. There is a paucity of studies regarding skin changes seen with changing hand hygiene practices in the Indian subcontinent. OBJECTIVES: To estimate the frequency of various cutaneous manifestations and associated factors with hand hygiene practices in doctors during COVID-19 via a web-based online questionnaire survey. METHODS: It was a cross-sectional web-based survey conducted at a tertiary care teaching institute from July 2021 to September 2021. Those doctors (faculty, residents, and interns) of the hospital completing the questionnaire with electronic informed consent were included in the study. RESULTS: A total of 143 doctors completed the survey. The most common symptoms were dryness in 60 (42%) and itching in 25 (17.5%) doctors. The most common skin changes were scaling in 30 (21%) and redness in 16 (11.2%) doctors. There was a significant association between skin changes and frequency of hand washing and hand sanitizer use (p value < 0.05). CONCLUSION: The prevalence of hand changes and symptoms was 77% in doctors in our study. The most commonly seen hand changes were scaling followed by redness and symptoms observed were dryness and itching.